S10.6 The NADPH binding on phagocyte NADPH oxidase
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چکیده
منابع مشابه
The phagocyte NADPH oxidase and bacterial infections
Neutrophils play a crucial role in host defense against microbial infections. During phagocytosis of invading bacteria or fungi, the phagocyte NADPH oxidase produces superoxide. The importance of the oxidase is exemplified by the genetic disorder known as chronic granulomatous disease (CGD). The neutrophils of CGD patients cannot produce superoxide, with the result that affected infants and chi...
متن کاملSTIM1 for stimulation of phagocyte NADPH oxidase.
In this issue of Blood, Zhang et al show that mice lacking the stromal-interacting molecule 1 (STIM1) gene in bone marrow cells are more susceptible to bacterial infection but are resistant to ischemia/reperfusion injury because of defective activation of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
متن کاملActivation of the Phagocyte NADPH Oxidase Protein p47
Activation of phagocyte NADPH oxidase requires interaction between p47 and p22. p47 in resting phagocytes does not bind p22. Phosphorylation of serines in the p47 C terminus enables binding to the p22 C terminus by inducing a conformational change in p47 that unmasks the SH3A domain. We report that an arginine/lysine-rich region in the p47 C terminus binds the p47 SH3 domains expressed in tande...
متن کاملSH3-dependent assembly of the phagocyte NADPH oxidase
F ~hagocytic cells contain a complicated enzyme system, termed NADPH oxidase, that is responsible for the production of toxic oxygen species (1). The enzyme transfers electrons from NADPH to 02, forming O2-, which then can dismutate into H202. Subsequently, other oxygen derivatives, such as hydroxyl radical and hypochlorous acid, may be formed. Collectively, these oxygen products are toxic to c...
متن کاملThe HIV-1 Nef protein and phagocyte NADPH oxidase activation.
Nef, a multifunctional HIV protein, activates the Vav/Rac/p21-activated kinase (PAK) signaling pathway. Given the potential role of this pathway in the activation of the phagocyte NADPH oxidase, we have investigated the effect of the HIV-1 Nef protein on the phagocyte respiratory burst. Microglia (cell line and primary culture) were transduced with lentiviral expression vectors. Expression of N...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2008
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2008.05.232